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Date: 04 07 98ISR Number: 3153614-3Report Type: Periodic Age: 55 YR Gender: Female I FU: I Outcome Dose 300 Urinary Incontinence MILLIGRAMS 2.0 DAILY PT Duration Polyuria Health, for example, zanaflex abuse. Ambitious aims are set for the year 2007. To reach these aims the team of the SCQM Office will be completed so that the SCQM Office will have sufficient resources to manage the three registers Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic Arthritis. For the first half of the year it is planned to finish the restructuring of the SCQM databases. The RA database should be operative in late spring-time using new questionnaires and a new feedback report. In early summer the development of the PsA database will be started. The opportunity will be used to revise the PsA questionnaires as well. Concerning the technical aspects, the SCQM FOUNDATION would like to purchase an X-ray scanner to scan the X-rays in the office. Up to now the X-rays for the RA register are digitalised at the University Hospital of Zurich. The AS X-rays are managed at the University Hospital in Lausanne. If the means are available, an X-ray scanner will be implemented in the second half of the year 2007. This will allow a more efficient handling of the X-rays resulting in a better quality than before. Since the SCQM FOUNDATION has one of the largest X-ray databases of the world with a long-time follow-up of many years, it is indispensable to invest in an improved quality of this part of the registers. Another important part will be the use of the three registers for scientific studies. The new technical structure of the databases will facilitate the analysis of the data. Furthermore, the AS and PsA registers have now sufficient patients included to expect sound results when analysing them. During the past years the SCQM Office was struggling to manage the routine work, namely the management of the incoming questionnaires and the data. The field of communication could not be handled sufficiently because of lacking resources. It is one important goal for 2007 to considerably improve the communication part of SCQM. Various measures and activities are in the process of evaluation. Furthermore, international contacts will be established, intensified and maintained. Other registries, like the Portuguese register or the CORRONA register from the US, are interested to cooperate. A great event took place on March 17th, 2007. A symposium on Ankylosing Spondylitis was organised of the Swiss Ankylosing Spondylitis Society SASS in cooperation with the AS Commission. The organisation started already quite early in 2006 and internationally well known experts in this field committed their attendance. The SCQM Office plans to be present again at the yearly joint congress of the Swiss Society for Rheumatology and the Swiss Society for Physical Medicine and Rehabilitation. It will take place at the end of August in Interlaken. In 2007 the SCQM registry will have its 10th birthday. It is still in the planning phase how to celebrate this event. The SCQM FOUNDATION will continue to deliver the best service to all relevant partners in the Swiss health care system including the participating rheumatologists and their patients, the partners and sponsors as well as the health care authorities. SCQM and its instruments is in the meantime an established cornerstone in the treatment of rheumatic diseases. The SCQM FOUNDATION will further improve and expand its role in the quality management of the treatment of rheumatic diseases. 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Preservation of Systolic Cardiac Function in the Absence of Cardiomyocyte PPAREchocardiographic assessment was used to evaluate resting systolic cardiac function in 6-month-old CM-PGKO mice and their littermate controls. There were no significant differences between the 2 groups with respect to measures of systolic function Table 1 ; . Not surprisingly, although the differences did not reach statistical significance, there was a trend toward slight increases in the left-ventricular FS, EF, cardiac index, and Vcfc in 6-month-old CM-PGKO mice, suggesting that there may be a subtle improvement in systolic function as a result of increased numbers of contractile units. It supports that the cardiac hypertrophy noted in the CM-PGKO mice is likely to be a primary effect of increased contractile protein synthesis and not a compensatory process attributable to diminished cardiac systolic performance. Interestingly, there was a significantly lower resting HR in the CM-PGKO mice.

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