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From the Department of Pharmacology, State University of New York, Health Science Center, Syracuse, N.Y. P.A.M. and O.M.B. ; and Division of Pharmacology, Department of Medicine, University of California, San Diego, La Jolla, Calif. J.H.B. ; This work was supported by a Grant-in-Aid from the American Heart Association with funds contributed in pan by the Broome County, New York, Chapter of the American Heart Association. J.H.B. is an Established Investigator of the American Heart Association. Ms. McGrattan's present address: The Perkin-Elmer Corporation, Norwalk, CT 06859. Address for reprints: Oliver M. Brown, Pharmacology Department, SUNY Health Science Center, 766 Irving Avenue, Syracuse, NY 13210. Received October 3, 1986; accepted December 31, 1986 and terbinafine.

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Technology Perimetry FDT ; N-30, a visual function specific test targeting magnocellular ganglion cells. Design: Cross-sectional analysis of an observational cohort study. Participants : One eye of 259 participants was evaluated: 51 normals, 56 ocular hypertensives OHT ; , 118 eyes with glaucomatous optic neuropathy GON ; and 34 with progressive GON PGON ; , a more stringent criteria to increase probability that glaucoma is present. Methods : Cross-sectional analysis. Visual fields were not used to classify groups. PGON, the best gold standard currently available for evaluation of functional tests, was documented by evidence of progressive change in optic disc appearance on masked review of simultaneous stereophotographs by two experts. Main outcome measures : Areas under the ROC for FDT indices and number of defective locations at various probabilities on the pattern and total deviation plots using area under the ROC. ROC results were then used to establish criteria for abnormality at different specificities. Results: Results are shown in Table 1 for parameters with largest ROC areas. Also shown are sensitivities at set specificities along the ROC curve for the PGON group Table 2 ; . Within a diagnostic group, no significant differences were found in areas under the ROC for the parameters evaluated. Conclusions : When comparing visual function specific tests with each other, with standard perimetry, or with measures of optic nerve structure it is important to utilize the best criteria for abnormality for each type of test. It is also important to take into account the trade-off in sensitivity vs. specificity for the particular use in question. The FDT N-30 test performs well in separating normal and glaucomatous eyes using a variety of parameters as evidenced by the large area under the ROC. Support: Grants NEI EY 08208 PAS ; and EY11008 LMZ ; References : 1. Burnstein Y, Ellish, NJ, Magbalon M, Higginbotham EJ: Comparison of frequency doubling perimetry with humphrey visual field analysis in a glaucoma practice. J Ophthalmol, 2000. 129 3 ; : p. 328-33. 2. Cello KE, Nelson-Quigg JM, Johnson CA: Frequency doubling technology perimetry for detection of glaucomatous visual field loss. J Ophthalmol, 2000. 129 3 ; : p. 314-22. 3. Johnson CA, Samuels SJ: Screening for glaucomatous visual field loss with frequency-doubling perimetry. Invest Ophthalmol Vis Sci, 1997. 38 2 ; : 413-25. Medeiros FA, Sample PA, Weinreb RN: Frequency doubling technology perimetry abnormalities as predictors of glaucomatous visual field loss. J Ophthalmol, 2004. 137 5 ; : p. 86371. 4. Paczka JA, Friedman DS, Quigley HA, Barron Y, Vitale S: Diagnostic capabilities of frequency-doubling technology, scanning laser polarimetry, and nerve fiber layer photographs to distinguish glauocmatous damage. J Ophthalmol, 2001. 131: p. 188-197. 5. Sample PA, Bosworth CF, Blumenthal EZ, Girkin C, Weinreb RN: Visual function-specific perimetry for indirect comparison of different ganglion cell populations in glaucoma. Invest Ophthalmol Vis Sci, 2000. 41 7 ; : 1783-90. 6. Wu LL, Suzuki Y, Kunimatsu S, Araie M, Iwase A, Tomita G: Frequency doubling technology and confocal scanning ophthalmoscopic optic disc analysis in open-angle glaucoma with hemifield defects. J Glaucoma, 2001. 10 4 ; : 256-60. P094 SENSITIVITY OF A NEW BLUE-ON-YELLOW SPARSE MVEP IN THE DETECTION OF GLAUCOMATOUS VISUAL FIELD DEFECTS. A. Klistorner, A. Martins, S. Graham, J. Grigg, I. Goldberg, F. Billson Sydney University, Sydney, Australia. 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