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Crime associated with marijuana. Marijuana is not at the level of cocaine or heroine, and this should be recognized. IMPACT STATEMENT The proposed resolution would not affect other statutes. AUTHOR AND OR PERMANENT CONTACT: Carter Stewart, McCutchen, Doyle, Brown & Enersen, LLP, Three Embarcadero Center, San Francisco, CA 94111-4067, Telephone: 415 ; 3932000, Facsimile: 415 ; 393-2286, E-mail: cstewart mdbe . RESPONSIBLE FLOOR DELEGATE: COUNTERARGUMENT SANTA CLARA COUNTY BAR ASSOCIATION One does not have to agree with all aspects of the so-called "war on drugs" to oppose this resolution. The statement of reasons is long on conclusions but short on facts to support them. E.g., "losing the war on drugs, " "a very large portion of the country especially those in California want the legislation, " "wasting millions of dollars, " "putting nonviolent individuals in jail or prison, " "legalization would reduce the crime." ; The proponents final request is that "Marijuana is not at the level of cocaine or heroin, and this should be recognized." In fact, this difference has been recognized in California law for decades. Possession of less than an ounce of marijuana has been a special kind of misdemeanor not subject to arrest, maximum penalty is a fine of $100 ; since the mid-seventies. Possession of heroin or cocaine is an alternate felony-misdemeanor "wobbler" ; . Health & Safety Code sections 11350, 11357 b ; , 11377. Passing this resolution would mean there are no state limits on anyone possessing, using, cultivating, transporting or selling marijuana. No limits on the age of the person who could engage in any of these acts. No limits on the amount of marijuana involved. Even NORML, in its 1996 policy statement, favors limiting use of cannabis to adults acting responsibly. Then there's that pesky "Supremacy Clause" of the United States Constitution to deal with because many of these acts are also illegal under the Federal Controlled Substances Act, 21 U.S.C. Section 2101 et. seq. Recently, the United States Supreme Court enforced those laws, even in what appeared to be a compelling case for a "medical necessity" defense. See U.S. v. Oakland Cannabis Buyers' Cooperatives, 532 U.S. 483; 149 L.Ed.2d 722; 121 S. Ct. 1711 2001 ; Our delegation supports reasonable changes in the California drug laws but we cannot support this one.

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An Active- Comparator and Placebo-Controlled, Parallel- Group, Double- Blind, 52 Week Study to Assess the Safety to Assess the Safety and Efficacy of MK-0663 in Rheumatoid Arthritis Patients" 1545 ; Protocol MK-0663 024-Merck Principal Investigator: Francis X. Burch, M.D. "An Open- Label, Long- Term Study to Evaluate the Safety of Prorgaf for the Treatment of Rheumatoid Arthritis" 1421x1 ; Protocol 98-0-151-Fujisawa Principal Investigator: Francis X. Burch, M.D. "A Multicenter, Randomized, Blinded, Placebo Controlled Study to Describe Long-Term Safety of Daily Subcutaneous Injections of Anakinra in Patients With Rheumatoid Arthritis" 2499 ; Protocol 990757-Amgen Principal Investigator: Francis X. Burch, M.D. "A Multi Center, Blinded, Randomized, Placebo-Controlled Trial to Study the Ability of anakinra to Retard Joint Destruction and Evaluate the Long Term Safety of IL-1ra anakinra ; in Subjects with Rheumatoid Arthritis" 2763 ; Protocol 990145-Amgen Principal Investigator: Francis X. Burch, M.D. "A Four Week Comparative Study Evaluating Acetaminophen Extended Release 3900 mg day ; in the Treatment of Osteoarthritis of the Knee" 2440a1 ; Protocol 99-090-McNeil Principal Investigator: Francis X. Burch, M.D. "Double-Blind, Placebo-Controlled, Parallel Group, Dose Ranging Comparison of the Efficacy and Safety of Controlled Release Oxymorphone and Placebo in the Treatment of Osteoarthritis of the Knee and or Hip" 2635 ; Protocol EN3202-015-Endo Principal Investigator: Francis X. Burch, M.D. "Clinical Protocol For a Multicenter, Double-Blind, Placebo-Controlled, Randomized Comparison Study Of The Efficacy and Upper Gastrointestinal Safety of Valdecoxib in Treating the Signs and symptoms of Osteoarthritis of the Knee" 1429 ; Protocol N91-99-02-053-Searle Principal Investigator: Francis X. Burch, M.D. "Randomized, Multi-Center, Multi-Dose, Double-Blind, Double-Dummy, Parallel-Group Study Comparing the Efficacy and Safety of Sustained-Release Oxycodone SR to Placebo in the Treatment of Pain Associated with Osteoarthritis", 2765 ; Protocol XSR0100-Roxane Principal Investigator: Francis X. Burch, M.D. "Double-Blind, Randomized, Placebo-Controlled Study of Enbrel in the Treatment of Rheumatoid Arthritis Subjects With Comorbid Disorders" 2767 ; Protocol 016.0029-Immunex Principal Investigator: Francis X. Burch, M.D. "Double-Blind, Randomized, Placebo-Controlled Phase III Study of Enbrel in the Treatment of Psoriatic Arthritis PsA ; and Psoriasis" 2804 ; Protocol 16.0030-Immunex Principal Investigator: Francis X. Burch, M.D. "Double-Blind, Randomized, Parallel-Group, Placebo Controlled Trial to Evaluate the Efficacy and Safety of Hydromorphone Extended-Release 12 mg Capsules Compared to Placebo in Patients with Osteoarthritis who Have Moderate to Severe Pain." 2900 ; Principal Investigator: Francis X. Burch, M.D and pheniramine!

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The transplant sector continues to be dominated by Roche, Astellas and Novartis these three companies captured 85% of the global market in 2006. Although demand for immunomodulators within the transplant sector will continue, we are only expecting a modest CAGR throughout the forecast period, due to the limited growth that is expected from products other than Roche's Cellcept and Astellas' Prograf. This reflects the attitude of physicians in this arena, who are reluctant to use anything other than these established products. Indeed, despite both products losing US patent protection in the near future Prpgraf in 2008 and Cellcept in 2009 ; , we are expecting limited generic penetration due to physician loyalty. New products are generally introduced in combination with mature products, such as ciclosporin and glucocorticoids, and can take a significant amount of time to establish themselves. In terms of novel compounds, the pipeline is weak, with Roche's belatacept the only product of note in development. Indeed, the transplant arena continues to be a graveyard for R&D compounds, with Novartis and Astellas discontinuing development of FTY-720 and FK-778 respectively, in the last 18 months. For the future, we expect Cellcept and Prlgraf to continue to dominate the transplant sector, driven by physician loyalty and a lack of generic penetration. MYFORTIC PEDIARIX PEGASYS PEG-INTRON REDIPEN 150MCG 0.5ML KIT PROGRAF PROTOPIC RAPAMUNE RAPTIVA REBETRON REBIF RECOMBIVAX RIDAURA ROFERON-A THALOMID TRIPEDIA TWINRIX VARICELLA-ZOSTER IMM GLOBULIN VARIVAX VACCINE VIVOTIF BERNA XOLAIR INFLAMMATORY BOWEL DISEASE AGENTS ASACOL CANASA CELESTONE COLAZAL DIPENTUM ENTOCORT EC mesalamine PENTASA sulfasalazine OPHTHALMIC AGENTS acetazolamide ACULAR ACULAR PF and propafenone. Many drugs are being released and kept on the market despite evidence of serious side effects.
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