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CONSUMER SEGMENT: Consumer segment operating profit in 2005 increased 10.2% over the prior year. As a percent to sales, 2005 increased slightly to 17.5%, despite increases in investment spending in advertising and research and development. Consumer segment operating profit in 2004 increased 9.5% over the prior year. As a percent to sales, 2004 experienced a decrease of 0.4% from 2003, primarily due to additional investment in consumer promotions and advertising in the Over-the-Counter Pharmaceuticals and Nutritionals franchise. PHARMACEUTICAL SEGMENT: In 2005, Pharmaceutical segment operating profit decreased 13.7%, and as a percent to sales declined 4.8% from 2004 to 28.5%. This change was primarily due to increased investment in research and development spending, as well as the impact of $302 million of IPR&D expenses in 2005. In 2004, Pharmaceutical segment operating profit increased 30.5% and reflected an operating profit as a percent to sales improvement of 4.4% over 2003 to 33.3%. This change was primarily due to the impact of $737 million of IPR&D expenses in 2003. MEDICAL DEVICES AND DIAGNOSTICS SEGMENT: In 2005, the Medical Devices and Diagnostics segment operating profit increased 33.5%, and as a percent to sales increased 4.2% from 2004 to 27.4%. This increase was driven by improved gross margins due to cost reduction programs and product mix, primarily related to the CYPHER R ; Sirolimus-eluting Stent. This was partially offset by an increased investment in research and development spending. In 2004, the Medical Devices and Diagnostics segment operating profit increased 22.9%. The increase over the prior year was achieved through improved gross margins, resulting from cost reduction programs and product mix, and the impact of $181 million of IPR&D expenses related to acquisitions in 2003. INTEREST INCOME ; EXPENSE: Interest income in 2005 increased by $292 million due primarily to higher rates of interest, as well as a higher average cash balance. The cash balance, including current marketable securities, was $16.1 billion at the end of 2005 and averaged $14.3 billion, as compared to the $11.3 billion average cash balance in 2004. Interest expense in 2005 decreased as compared to 2004 due in part to a decrease in the average debt balance, from $3.5 billion in 2004 to $2.6 billion in 2005. Interest income in 2004 increased by $18 million due primarily to a higher cash balance. The cash and marketable securities combined balance at the end of 2004 was $12.9 billion and averaged $11.3 billion, which is significantly higher than the $8.6 billion average cash balance in 2003. Interest expense in 2004 decreased by $20 million as compared to 2003 primarily due to a decrease in the average debt balance, from $5.0 billion in 2003 to $3.5 billion in 2004. PROVISION FOR TAXES ON INCOME: The worldwide effective income tax rate was 23.3% in 2005, 33.7% in 2004 and 29.9% in 2003. The decrease in the tax rate was attributable to a tax benefit of $225 million, recorded in 2005, related to a technical correction associated with the American Jobs Creation Act of 2004. Also contributing to the decrease in the 2005 tax rate was the increase in taxable income in lower tax jurisdictions relative to taxable income in higher tax jurisdictions, as a result of increased expenditures in higher tax jurisdictions and a shift in sales mix. These benefits were partially offset by non-deductible IPR&D charges. The increase in the effective tax rate in 2004 was primarily due to the $789 million tax cost on the intended repatriation of undistributed international earnings associated with the American Jobs Creation Act of 2004, which added 6.4% to the effective income tax rate. LIQUIDITY AND CAPITAL RESOURCES CASH FLOWS Cash generated from operations and selected borrowings provide the major sources of funds for the growth of the business, including working capital, capital expenditures and acquisitions. Other uses of cash include share repurchases, dividends and debt repayments. In 2005, cash flow from operations was $11.8 billion, an increase of $0.7 billion over 2004. The increase in cash generated from operations was a result of a net income increase of $2.2 billion, net of the non-cash impact of IPR&D charges. A $1.0 billion decrease in other current and non-current assets also contributed to this increase. This was partially offset by a $1.5 billion decrease in accounts payable and accrued liabilities. Additionally, cash payments of approximately $0.5 billion were made for previously accrued taxes on the repatriation of undistributed international earnings in accordance with the American Jobs Creation Act of 2004. There was also an increase of approximately $0.2 billion in pension funding in 2005 as compared to 2004. Net cash used for investing activities decreased by $2.1 billion in 2005 due to a $3.1 billion net increase in the sales of investments. This was partially offset by a $0.5 billion increase in capital expenditures and a $0.4 billion increase in acquisition activity. For a more detailed discussion on mergers and acquisitions, see Note 17. Net cash used for financing activities decreased by $0.7 billion in 2005 due to a net issuance of debt partially offset by an increase in dividends and increased levels of common stock repurchases. Cash and current marketable securities were $16.1 billion at the end of 2005 as compared with $12.9 billion at the end of 2004. Cash generated from operations amounted to $11.1 billion in 2004, which was $0.5 billion more than the cash generated from operations in 2003 of $10.6 billion. The major factor contributing to the increase was a net income increase of $0.4 billion, net of the non-cash impact of IPR&D charges. PAGE 34 JOHNSON & JOHNSON 2005 ANNUAL REPORT and hydrocodone. 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Acetylcholinesterase Inhibitors . Overview . Mechanism of Action . Phenserine . GABA Receptor Inverse Agonists . 103 Overview . 103 Mechanism of Action . 103 S-8510 . 103 Neurotransmitter Modulators . 105 Overview . 105 Mechanism of Action . 105 NS-2330 106 CX-717 107 Xaliprodene SR-57746A ; 109 SR-57667B 111 SL-65.0155 111 Beta-Amyloid Aggregation Inhibitors . 113 Overview . 113 Mechanism of Action . 114 Alzhemed NC-531 ; 114 Anti-Beta-Amyloid Neuroprotectants . 118 Overview . 118 Mechanism of Action . 119 PBT-1 Clioquinol ; . 119 Beta-Amyloid Generation Inhibitors . 124 Overview . 124 Mechanism of Action . 124 b-Secretase Inhibitors . 125 Beta-Amyloid Immunization . 126 Overview . 126 Mechanism of Action . 128 ACC-001 130 M266 Passive Immunization ; . 131 Nonsteroidal Anti-Inflammatory Drugs . 132 Overview . 132 Mechanism of Action . 133 R-Flurbiprofen 133 Phosphodiesterase Inhibitors 136 Mechanism of Action . 136 MEM-1414 137 Gene Therapy . 138 Overview . 138 Mechanism of Action . 138 CERE-110 NeuroRescue AD ; 140 and hyzaar.
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Insulin glargine vials only ; LANTUS GLUCOSE ELEVATING AGENTS glucagon GLUCAGON L ; L ; limit 2 per year DIABETES SUPPLIES TrueTrack meters and strips ketone strips only if on insulin ; KETOSTIX lancets and syringes ORAL MEDICATIONS Sulfonylureas glyburide * DIABETA glipizide * GLUCOTROL glipizide ext. rel * GLUCOTROL XL glimepiride * AMARYL Non-Sulfonylureas acarbose PRECOSE metformin * GLUCOPHAGE metformin ext. rel. * GLUCOPHAGE XR rosiglitazone AVANDIA PA ; pioglitazone ACTOS PA ; Combination Products glyburide metformin * GLUCOVANCE OSTEOPOROSIS AGENTS estradiol * ESTRACE calcitonin salmon, nasal spray MIACALCIN estrogens, conjugated PREMARIN estrogens, esterified * MENEST alendronate FOSAMAX risedronate ACTONEL estrogens, conjugated PREMPRO medroxyprogesterone PREMPHASE Updated on 10 2006 00 PM. Use of PIs. Retrospective analyses have offered conflicting evidence about whether antiretroviral agents increase the risk of coronary artery disease.16, 17 When intervention is indicated, a lipid-management program emphasizing dietary adjustments should be implemented. Because of the potential for substantial toxicity, the dosages of antihyperlipidemic agents should be reduced when they are taken with PIs. Ritonavir Norvir ; increases serum levels of simvastatin Zocor ; and can cause myalgias, rhabdomyolysis, renal failure, and liver damage. PIs should not be used concurrently with simvastatin or lovastatin Mevacor pravastatin Pravachol ; is the safest statin to use with PIs.7 Because of the potential for enhanced statin-related toxicity, atorvastatin Lipitor ; and fluvastatin Lescol ; should be used with caution and in lower dosages when taken with PIs.7 Serum lipid abnormalities have resolved in some patients after discontinuing PI therapy and starting PI-sparing regimens.1 However, this step requires a risk-benefit analysis in consultation with an infectious disease or HIV specialist. Monitoring fasting glucose levels every three to six months is useful in patients taking PIs because of the potential for developing glucose intolerance, insulin resistance, and type 2 diabetes. PIs can aggravate existing diabetes; patients with HIV infection who also have diabetes should be monitored closely when PIs are prescribed.1 Diet, exercise, and weight loss are preferred over hypoglycemic drug therapy, although agents such as thiazolidinediones or metformin Gl7cophage ; can be considered.1 and ibuprofen. Glucophage xr glucotrol xl glucovance glyburide humalog humulin-n hydrocodone hydrochlorothiazide and sulphur allergies apap.
METHODS A pilot study was carried out, promoted, and coordinated by the Clinical Pharmacology Department of "Virgen Macarena" University Hospital Seville, Spain ; to test a model for the detection of hepatotoxic ADRs. The main demographic and clinico-therapeutic characteristics of the patients included are summarized in table I. The model, applied between June 2002 and July 2003, is based on the identification of a single alert signal in various target departments within the hospital. Alert signals raising suspicion of drug-induced liver toxicity may include the following 7 ; : a ; GPT; b ; 0.6 mg dL of conjugated bilirubin; c ; 80 U L GOT, 2 mg dL of total bilirubin, and 516 U L of alkaline phosphatase simultaneously ; . The presence of just one of them was sufficient to generate suspicion. The choice of target departments was based on the number of consultations for suspected drug-induced hepatotoxicity received in the Hepatology Unit Gastroenterology Department ; . They comprised the following: In and imitrex.

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