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FosamaxWiwanitkit, V. Imiquimod: a new immunomodulatory drug. Chula Med J 2004 May; 48 5 ; : 325 - 38 Imiquimod a recently developed imidazoquinolin heterocyclic amine belongs to a new class of drug, immune response modifier agents, which can be attributed to the induction of a number of cytokines including interferon-alpha IFN-alpha ; , interferon-gamma IFN-gamma ; , tumor necrosis factor-alpha, interleukins-1, -6, -8, -12. Imiquimod increases in interferon and tumor necrosis factor in cultures of cells isolated from animal skin, and increases interleukin-8 concentrations in human keratinocyte and fibroblast cultures. Although in vitro studies have shown that imiquimod has no direct antiviral effects, the drug does exhibit antiviral and antitumor effects in vivo through induction of human cytokines. Although imiquimod cream recently became available for the treatment of genital and perianal warts, the topical mechanism of action of imiquimod is not yet fully understood. It is believed that stimulation of local cytokines by imiquimod leads to a reduction in human papilloma virus HPV ; load; to wart regression and to the normalization of keratinocyte proliferation without evidence of scarring. Treatment with topical 5 % imiquimod cream has shown promising results in the treatment of genital warts in immunocompetent individuals. Furthermore, it is an interesting alternative therapeutic method for other cutaneous viral skin lesions among immunocompetent and HIV-infected patients. Keyword : Imiquimod. Reprint request : Wiwanitkit, V. Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Received for publication: January 15, 2003. Objective : To introduce a new drug, imiquimod, to the reader. Prescribed pain medication just before bedtime. If pain wakes you, position with pillows, rolled towels, or blankets placed to keep your chest aligned or leg incisions from rubbing, for example, dizziness.
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