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Take LEXIVA Tablets exactly as your healthcare provider prescribed. Do not take more or less than your prescribed dose of LEXIVA Tablets at any one time. Do not change your dose or stop taking LEXIVA without talking with your healthcare provider. You can take LEXIVA Tablets with or without food. When your supply of LEXIVA or other anti-HIV medicine starts to run low, get more from your healthcare provider or pharmacy. The amount of HIV virus in your blood may increase if one or more of the medicines are stopped, even for a short time. Stay under the care of a healthcare provider while using LEXIVA. It is important that you do not miss any doses. If you miss a dose of LEXIVA by more than 4 hours, wait and take the next dose at the regular time. However, if you miss a dose by fewer than 4 hours, take your missed dose right away. Then take your next dose at the regular time. If you take too much LEXIVA, call your healthcare provider or poison control center right away, for example, atenolol. The recommended treatment involves a combination antibiotic called trimethoprim-sulfamethoxazole, also known as bactrim or septra.
If you have ever had mental illness or are using drugs or alcohol. Rash is a common side effect that usually goes away without any change in your medicines. Rash may be a serious problem in some children. If you have liver disease, have ever had seizures, or are taking medicine for seizures, your healthcare provider may want to do tests to check your liver or check drug levels in your blood, because doxycycline. Ideation, suicide attempts, and suicide. The F D A also found Accutane promotional advertisements to contain false and misleading information. It took an F D letter for Roche U S to strengthen its warnings. : accutane-side-effects This episode does not stand alone. On 01-05-98 the F D A New Jersey District Director informed the President and C E O Roche U S that it was not submitting Adverse Drug Experience reports within the required fifteen working days while noting a 2 year to over 8 year delay for 13 of its products, some 5 years for Bactrim. A 05-29-03 letter from the F D A Director of the Division of Drug Marketing , Advertising, and Communications to the president and C E O Roche U S complained of Roche's direct to consumer promotional materials for Xeloda, an anti-cancer drug, that was misleading as it failed to present risk information as to serious potentially life threatening risks while making unsubstantiated efficacy claims as well. It seems that what a serious "Black Box Warning" gave, promotional material for consumers took away. A video reportedly downplayed adverse events through patient testimonials minimizing the severity and importance of risks. The letter requested that Roche U S cease dissemination of these and similar materials, formulate a plan of action to disseminate accurate and complete information to audiences who received the violative materials, and send a written statement of intent to comply. : fda.gov foi warning letters g4059d. 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A dose of 625 cc would provide 30mg bactrim for a pig of one kilo 2 pounds.
Peripheral vascular disease results in obstruction that reduces blood flow to distal tissues or disease of the vascular wall that predisposes patients to aneurysm formation. The prevalence of PVD ranges from 3% in patients 55 to 11% in patients 65 to 20% in those 75 and older.12 The most common problems due to PVD seen by primary care physicians are cerebrovascular carotid disease, abdominal aortic aneurysms, and peripheral occlusive disease. Renal artery obstruction contributing to hypertension and renal insufficiency is common and often overlooked. Carotid artery disease, particularly at the bifurcation of the internal and external branches is a common finding in the older population. If the vessel is very narrow due to increasing amounts of plaque, the result may be embolization to the distal circulation, especially the middle cerebral artery, with resultant ischemic stroke. Stroke is the third leading cause of death in the United States, affecting 5% of those over 69 each year.12 After the initial stroke, approximately one fourth will not survive. Of those who survive, only 30% will subsequently function normally. Without intervention, one third of the stroke victims will have recurrent strokes. What are risk factors for stroke other than advancing age and blood elevated pressure? Risk factors that may be modifiable include cigarette smoking, diabetes mellitus, carotid artery disease, heart disease, particularly atrial fibrillation; transient ischemic attacks, excessive alcohol intake, and drug abuse . Identification of patients with transient ischemic attack TIA ; or prior stroke is also important, offering opportunities for intervention with rapid intervention documented to be very important in the patient with TIA. Most recently, regions of stroke susceptibility have been identified on chromosome 5 for Icelandics and confirmed in North Americans. The genomic approach should allow additional avenues for interventions in the future. Prevention is key in this disease as the prognosis is generally grim. With the diagnosis of carotid artery disease made by history, physical exam and imaging studies, what can be done? There have been 3 national trials13, 14, 15 that randomized patients to medical therapy with aspirin or carotid enarterectomy plus aspirin. In symptomatic patients with more then 50% carotid stenosis and asymptomatic patients with 60% carotid stenosis, surgery was the most effective means of stroke prevention and cabergoline, for example, bactrim ointment.

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D. Headache, dizziness, and diarrhea. 11. During aliskiren therapy, hyperkalemia: A. Is a common side effect, which requires close monitoring in all patients. B. Occurred most frequently in patients with diabetes receiving a concomitant ACE inhibitor. C. Occurred most frequently in patients with impaired renal function. D. Was not a reported side effect. 12. A pharmacokinetic drug interaction has not been observed and cafergot. Objective: Viewing R-rated movies significantly increases the risk of adolescent smoking initiation, even after controlling for social and parental influences. This study examines whether parental co-viewing of R-rated movies reduces this association. Methods: We surveyed 2560 adolescents, 9-12 years, by telephone and assessed their susceptibility to smoking and parental rules about movie viewing. We asked children how often their parents let them watch R-rated movies and how often they watch R-rated movies with their parents. Results: Overall, 10% of the children were susceptible to smoking. Slightly more than half 55% ; reported that their parents allowed them to watch R-rated movies. Of these, 21% were allowed to watch R-movies most of the time and 79% could watch them sometimes. Parental permission to watch R-movies was significantly associated with increased susceptibility to smoking 14% of those who were allowed to watch R-movies were susceptible compared to 5% of those who were never permitted to watch them [p 0.0001] ; . Parental co-viewing decreased the association between R-movie restrictions and susceptibility to smoking. Among children who watch R-rated movies, 21% of those who never watch them with their parents were susceptible compared to 11% of those who watch R-movies with their parents most or all of the time p 0.001 ; . Conclusion: Parental restriction of R-rated movies may be an effective strategy for decreasing the likelihood that a child will initiate smoking. However, if parents choose to let their children watch R-rated movies, co-viewing may mitigate some of the influence these movies have on the risk of adolescent smoking. CORRESPONDING AUTHOR: Madeline A. Dalton, PhD, Pediatrics, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH, USA, 03756; madeline.dalton dartmouth. March 9-13. International Conference on Healthcare Ethics - Abu Dhabi `Ethical considerations in resource allocation at the population level' February 22-24. HPTN Annual Conference Washington DC `Ethical considerations in HIV prevention trials' April 20-21. Europe-developing country partnership programme for research into diseases of poverty - Barcelona. `Research ethics in developing countries and the cultural context' May 3-4. 1st Annual Global Health Research Conference University of Toronto. The global context of medical research.' & `Research Ethics in developing countries' May 24-26. Sustainable Justice & Implementation of Sustainable Development Law Conference : Montreal ` International Sustainable Development: implications for health & health care.' May 17-18. Public Heath Ethics International Symposium Toronto `Concluding Summary Address' June 9. Harvard University of Toronto Health Management Course. "Understanding the New World of Health Care." Rotman Business School. Toronto, "Health care in a global context." 18 June. 5th International Conference on Medical Regulation Toronto. `Professionalism in a globalising world' June 22-23. G6 billion Peoples' Counter summit Conference Calgary ` Health ethics & allocation of resources on a global scale' October 12. European Forum for Philosophy. York UK `Medicine and Justice', October 30- November 3. 6th World Congress on Bioethics - Brasilia Presidential Address: 'Bioethics: Power and Injustice, ' & 'Public Health and Human Rights' December 2-3. Mdecins Sans Frontires, "Drugs for neglected diseases initiative DNDI ; Rio de Janeiro `Weighing the benefits and risk of medical research on neglected disease.' He also gave invited lectures at the University of Bahia in Salvador, Brazil, and at the University of Alberta in Edmonton, Canada and the Keynote Plenary Address `Globalization and health: expanding the discourse on ethics' ; at the Annual Conference of the American Society of Tropical Medicine and Hygiene Denver 10-14 November 2002 and calan. NACO also financed the modernisation of 815 blood banks: 727 public banks and 88 in to the charity sector NACO, 2001, 2003 ; . More precisely, it partly finances the purchase of equipment and consumables such as chemical and reactive products. NACO plans to expand its efforts by modernising 20 other large banks. In the same way, it plans to set up 80 new blood banks at district level. Table 12. Modernisation of blood banks in the public and voluntary sectors Year 1989-92 1992-93 1993-94 Total Main Banks 0 0 0 138 236 District Banks 80 100 Total 178 100.

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Conway Institute, Pharmacology Department, University College Dublin, Dublin, Ireland One of the main goals in functional genomics has been the development of tools that allow easy manipulation of gene expression levels, that would be suitable for high through-put screening. RNAi has emerged as one of the preferred approaches to achieve this goal. It is an important biological mechanism in the regulation of gene expression in animals and plants. Functional investigation of the complex regulation of molecular switches and their effectors are key to understanding nephrotoxicity. Nephrotoxicity is caused by several drugs such as immunosuppressive agents and is associated with the development of renal fibrosis. We have established several in vitro models of nephrotoxicity and have identified several key genes, using both micro-array and differential gene expression SSH ; technology, which we believe are involved in this process. We have used RNAi to analyse the role of these genes in the development of nephrotoxicity. A number of interesting differentially expressed genes involved in signal transduction, cell cycle regulation and cytoskeletal dynamics were identified and are being examined further as potential therapeutic targets. In conclusion we have demonstrated that silencing of key genes with RNAi has helped to elucidate their role in the development of renal fibrosis and nephrotoxicity. Further examination of these differentially regulated genes may lead to the identification of novel therapeutic targets and potential adjunct therapies. Finally we believe that the potential role of RNAi as an alternative to animal models is just beginning to be realised and capoten. Use has published guidelines describing these methodologies : fda.gov cber gdlns ichqt ; . Conclusions Drug-induced LQTS has been recognized as a major hurdle in the successful development of a new drug. The main cause of this acquired form of LQTS is due to drug-induced HERG channel block. A key feature is its unpredictable nature. QTc prolongation alone does not predict TDP. QTc dispersion may be also important, especially for the maintenance of this, for example, bactrim forte. 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Ndekha A. Strengthening community participation in schistosomiasis control: lessons from the Guruve District Zimbabwe ; schistosomiasis control programme using Phytolacca dodecandra a plant molluscicide ; . Copenhagen: The Royal Danish School of Pharmacy, Department of Social Pharmacy 2001, for example, breast feeding and bactrim. Pneumocystis carinii pneumonia PCP ; remains the most frequent AIDS defining diagnosis even in the era of potent antiretroviral therapy. As with many other opportunistic infections, the risk of PCP is inversely correlated to the CD4 count and is highest once CD4 counts drop below 200 cells mm3. In fact, only 5% of cases occur at higher CD4 counts. Because of the serious complications related to this infection, such as respiratory failure requiring admission to a specialized unit or even mechanical respiratory assistance in an intensive care unit, PCP is viewed as one of the most dangerous infections. Since 1992, prophylaxis for PCP and prevention of recurrent disease is recommended in HIV patients with CD4 counts below 200. Trimethoprim sulfamethoxazole Bactrim, Septra ; is considered the agent of choice because of its high efficacy in preventing PCP and other diseases such as toxoplasmosis, nocardiosis or other bacterial infections, low cost and relatively good tolerability. However, side effects are observed in about one third of patients, who will experience anything from fever, rash, diarrhea to liver toxicity. Other agents used are dapsone, aerosolized pentamidine, and atovaquone. These alternative regimens are substantially more expensive. Unlike MAC or CMV disease, where inflammation plays a very small role in the severity of the disease, severe PCP is associated with a spectacular inflammatory reaction in the lungs, causing massive leakage in the respiratory spaces followed by respiratory failure. Corticosteroids prednisone ; block this inflammatory response and have been shown to decrease the inflammation, reduce this early complication of PCP and result in an overall better outcome. Since the use of protease-inhibitor containing regimens, the rate of PCP has dramatically diminished in patients taking PCP prophylaxis. In a French study presented last year, PCP events decreased by 60% in 1997 compared to 1996. In another study, ACTG 320, only 6 of 577 patients on the indinavir containing arm developed PCP, mostly in the first 3 months after starting antiretrovirals. In addition, there were no cases of PCP in patients with CD4 counts above 140 cells mm3, indicating that the CD4 threshold for being at risk for PCP had not changed. In recent years there has been increasing evidence that the rises in CD4 counts following potent antiretroviral therapy are associated with renewed protection against infections. In other words, the immune system is undergoing reconstitution. These effects have been observed even in patients without adequate suppression of HIV replication. Some scientists speculate that this protection afforded by the CD4 rise is only possible if the opportunistic agent is sufficiently common or present in high quantities in the environment. We think this is true for Mycobacterium avium complex, Candida, cryptococcus, as well as diseases that are acquired well before HIV infection and that re-activate, such as Herpes simplex and Cytomegalovirus. Because PCP is present in the environment, patients who are responding to potent antiretroviral therapy, should be exposed to Pneumocystis and may acquire protection against new or recurrent disease. If this protection is granted by the renewed immune system, then stopping prophylaxis seems a reasonable option to allow patients to concentrate on taking their antiretroviral treatment. This step should only be done in the setting of a clinical trial for the moment, to ensure adequate protection to patients, see Stopping PCP Prophylaxis on page 7 and levodopa.

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Bradley Pharmaceuticals, Inc. and Subsidiaries NOTES TO CONSOLIDATED FINANCIAL STATEMENTS December 31, 2002 this date. As of December 31, 2002 and 2001, there were 2, 487, 000 and 2, 505, 000 shares available for grant, respectively.

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NDA 21-332 Page 18 Once Target Dose of SYMLIN Is Achieved in Type 2 or Type 1 Patients After a maintenance dose of SYMLIN is achieved, both insulin-using patients with type 2 diabetes and patients with type 1 diabetes should be instructed to: Adjust insulin doses to optimize glycemic control once the target dose of SYMLIN is achieved and nausea if experienced ; has subsided. Insulin dose adjustments should be made only as directed by a health care professional; Contact a health care professional in the event of recurrent nausea or hypoglycemia. An increased frequency of mild to moderate hypoglycemia should be viewed as a warning sign of increased risk for severe hypoglycemia. Popular medications accutane alprazolam ambien ativan bactrimm bromazepam buspirone carisoma celebrex cialis citalopram clonazepam codeine depakote diazepam dormicum effexor fludrocortisone flurazepam hydroxyzine imovane lasix levothyroxine lexotanil lipitor lorazepam meridia midazolam modafinil naltrexone neurontin paxil phenergan propecia proscar provigil prozac risperdal rivotril sibutramine sildefil soma strattera tamiflu tegretol tramadol trazodone tryptanol valium valtrex viagra xanax xenical zoloft zolpidem zyprexa zyrte serobid serevent ; -without prescription rotadisk 50mcg-4 x 15 dose manufacturer-cipla eedom rx pharm and ciprofloxacin. New drugs added since June 2002 indicated in bold. ANTIRETROVIRALS NRTIs- abacavir Ziagen ; , abacavir lamivudine zidovudine Trizivir ; , didanosine ddI, Videx ; , emtricitabine Emtriva ; , lamivudine Epivir, 3TC ; , lamivudine zidovudine Combivir ; , stavudine d4T, Zerit ; , tenofovir Viread ; , zalcitabine ddC, Hivid ; , zidovudine AZT, Retrovir ; . PIs- amprenavir Agenerase ; , atazanavir Reyataz ; , fosamprenavir Lexiva ; , indinavir Crixivan ; , lopinavir ritonavir Kaletra ; , nelfinavir Viracept ; , ritonavir Norvir ; , saquinavir Fortovase, Invirase ; . NNRTIs- delavirdine Rescriptor ; , efavirenz Sustiva ; , nevirapine Viramune ; . Other- hydroxyurea Hydrea ; . Entry Inhibitor- enfufuvirtide Fuzeon ; . OI DRUGS PHS "A1 OI"s- acyclovir Zovirax ; , azithromycin Zithromax ; , clarithromycin Biaxin ; , famciclovir Famvir ; , fluconazole Diflucan ; , ganciclovir Cytovene ; , itraconazole Sporonox ; , leucovorin, pyrimethamine Daraprim ; , sulfadiazine, TMP SMX Bactrim, Cotrim, Septra, Sulfatrim ; . Other OIs- atovaquone Mepron ; , ciprofloxacin Cipro ; , clindamycin Cleocin ; , dapsone, ethambutol Myambutol ; , ketoconazole Nizoral ; , nystatin Mycostatin, Nilstat ; , paromomycin Humatin ; , pentamidine NebuPent ; , rifabutin Mycobutin ; , valacyclovir Valtrex ; , valganciclovir Valcyte ; . Hepatitis C- none. ALL OTHERS amitriptyline Elavil ; , diphenoxylate Lomotil ; , lansoprazole Prevacid ; , loperamide Imodium ; , nortriptyline Pamelor ; , omeprazole Prilosec ; , ondansetron Zofran ; , pancrelipase Pancreas ; , prochlorperazine Compazine ; , promethazine Phenergan. Workshop Co-Leaders: Seth G. Parker, Vice President & Principal, and John J. Elder, P.E., Manager Power Systems & Market Design, LEVITAN & ASSOCIATES, INC. The three Northeastern ISOs have, or have proposed, different mechanisms to price installed capacity ICAP ; . The challenges to forecasting ICAP values in those markets are daunting. Only the NYISO mechanism is established. Both the ISO-NE and PJM proposals await FERC approval as well as acceptance from skeptical participants ; , and may change during the regulatory process. In the meanwhile, pressing capacity needs in constrained regions may require more immediate, non-market solutions. NYISO altered its Spot Market in 2003 to incorporate a sloped demand curve and three locational prices. The goal was to reduce bi-polar price volatility and to recognize the benefits of ICAP in excess of the state's requirement. The original ISO-NE LiCap proposal met with strong disagreement. An exhaustive settlement process culminated in a Forward Capacity Market FCM ; proposal that would utilize a descending clock auction, but there are uncertainties regarding locational pricing, net energy offsets, and performance requirements. After unsuccessfully trying to obtain participant support, PJM filed its Reliability Pricing Model RPM ; with FERC, which convened a Technical Conference to address fundamental issues. RPM would utilize a sloped demand curve with ICAP commitments years ahead of delivery and locations defined in advance. These market mechanisms are likely to have far-ranging impacts not only on the development and financing of new generation, but also on the revenue streams of existing projects, the economics of renewable assets and demand response programs, and on customer rates. This workshop will examine the major provisions of the three ICAP mechanisms and the key value drivers. We will provide a step-by-step guide to preparing forecasts of future ICAP prices in the Northeastern markets.

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ExpAnding tHe BlAck Box depression, AntidepressAnts, And tHe risk of suicide I n M antidepressant medications carry an expanded black-box warning incorporating information about an increased risk of suicidal symptoms in young adults 18 to 24 years of age. Since October 2004, antidepressants have been required to have a black-box warning indicating that they are associated with an increased risk of suicidal thinking, feeling, and behavior in children and adolescents. The new warning also states that there is no evidence of an increased risk for adults older than 24 years of age and that the risk is actually decreased for adults 65 years of age or older. The label states that "depression and other serious psychiatric disorders are themselves associated with increases in the risk of suicide, " and implies that there is risk in not using the very medication being warned about. The notion that antidepressants might be associated with an increased risk of suicidality in some patients is not new. In the first few weeks of treatment with antidepressants, some patients become "activated" -- energised and agitated -- before their depressed mood lifts, and that combination makes them more likely to act on preexisting suicidal impulses. But because suicidal thinking, feeling, and behavior are core symptoms of depression, there is no way to know whether suicidal symptoms that develop during treatment are due to the underlying illness or the medication. T h e comprehensive meta-analyses of an enormous data set on 99, 839 participants in 372 randomised clinical trials of antidepressants conducted by 12 pharmaceutical companies during the past two decades. No increased risk of suicidal behavior or ideation was perceptible when analyses were pooled across all adult age groups. However, in age-stratified analyses, the risk for patients 18 to 24 years of age was ele vated, but not sig nificantly odds r atio, 1.55; 95% confidence interval, 0.91 to 2.70 ; . However, the trend across age groups toward an association between antidepressants and suicidality was convincing when superimposed on earlier analyses of data on adolescents from randomised, controlled trials. However, there are some shortcomings in the meta-analyses considered by the FDA. The studies were designed primarily to assess shortterm efficacy, not long-term safety. The suicidal symptoms came from adverse-event reports, and this subject to ascertainment bias. Participants who report common side effects would be more likely to be asked about other adverse effects and might be more likely to report suicidal symptoms. Also, younger participants might be more likely than older participants to report adverse events. The meta-analyses also ignored attrition, which might have varied with age. But the greatest difficulty for interpretation is whether suicidality is caused by the disease or the treatment. About 20% of the data came from studies of treatment for nonpsychiatric indications for example, smoking cessation, insomnia ; and for nonbehavioral indications for example, fibromyalgia, diabetic neuropathy ; , but these data were not included in the, for instance, atenolol. A 37-year-old man sought medical attention when KS lesions began to appear on his body over the course of six months. Technicians performed CAT scans of his abdomen, which revealed that KS lesions were also inside his body in the following places: lymph nodes lungs spleen Blood tests found the following: CD4 + cell count 30 cells viral load 300, 000 copies the presence of anti-HHV-8 antibodies Although he was not taking anti-HIV drugs at the time, resistance testing revealed that his virus was resistant to indinavir Crixivan ; and nelfinavir Viracept ; , so doctors prescribed the following combination of drugs: efavirenz AZT Retrovir ; 3TC lamivudine, Epivir ; To prevent common AIDS-related bacterial infections he also received the following antibiotics: Bzctrim Septra azithromycin Zithromax and bromocriptine.

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These drugs have a spectrum of activity much broader than the organisms that cause pneumonia. Results are described as mean se with statistical significance considered at p table 1-protocol for lower-limb exercise during pr sessions results a total of 108 patients were randomized and received at least one dose of study medication. 1. The date an exemption under section 505 i ; of the Federal Food, Drug, and Cosmetic Act the act ; 21 U.S.C. 355 i became effective: May 17, 1990. FDA has verified the applicant's claim that the date the investigational new drug application became effective was on May 17, 1990. 2. The date the application was initially submitted with respect to the human drug product under section 505 b ; of the act: June 28, 2000. FDA has verified the applicant's claim that the new drug application NDA ; for IPRIVASK NDA 21-271 ; was initially submitted on June 28, 2000. 3. The date the application was approved: April 4, 2003. FDA has verified the applicant's claim that NDA 21-271 was approved on April 4, 2003. Is bactrim living all the drs bactrim saw in the body. This form must be completed and returned to Neville Registrars Limited, Neville House, 18 Laurel Lane, Halesowen, West Midlands B63 6DA not later than 12.00 p.m. on 10 September 2001 unless this deadline is extended by the Directors ; . If you post your Application Form you are recommended to use rst class post and to allow at least two business days for delivery. Applications must be for a minimum of 14, 000 New Ordinary Shares and thereafter in multiples of 1, 000 New Ordinary Shares. To: Henderson Morley plc Dear Sirs, Henderson Morley plc ``the Company'' ; Oer of up to 25, 437, 500 New Ordinary Shares of 0.125 pence each at 4 pence per share payable in full on application I We hereby irrevocably oer to subscribe for . New Ordinary Shares of 0.125 pence each in the capital of the Company at 4 pence per share or any smaller number of New Ordinary Shares for which this application is accepted ; , on the terms of the Company's prospectus dated 24 August 2001 ``the Prospectus'' ; and subject to the terms and conditions set out overleaf and the memorandum and articles of association of the Company. I We enclose my our cheque for . being the amount payable in full for the number of New Ordinary Shares stated above, made payable to ``Neville Registrars Limited a c Henderson Morley plc'' and crossed ``a c payee''. I We wish to claim EIS Relief * delete as appropriate ; Yes No * I We request that you forward to the rst-named person below by post at his her risk a denitive certicate in respect of the New Ordinary Shares allocated to me us and or a cheque for any monies returnable to the address rst given below. I We request and authorise you to register any New Ordinary Shares for which this application is accepted in the name s ; set out below. Please complete using BLOCK CAPITALS Forename s ; Name of Corporation . Surname. Address Capacity if signing on behalf of a Corporation . Signed . Date . The signature on behalf of a corporation must be that of a duly authorised ocial who should state his her representative capacity. Intermediaries claiming commission should stamp the box below Stamp of Intermediary SRO and Membership Number.

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